Weight Management · Oral GLP-1

Real weight loss. One pill, once a day.

Orforglipron · once-daily oral tablet · by Eli Lilly

Foundayo™ (orforglipron) is the FDA-approved oral GLP-1 that helps eligible adults lose meaningful weight — no injections, no special fasting window, just one tablet a day guided by a licensed provider.

  • Clinically studied weight-loss results — see the data below
  • Once-daily tablet, with or without food
  • Provider-guided titration from 0.8 mg up to 17.2 mg when appropriate

Prescription required. Foundayo™ is used with a reduced-calorie diet and increased physical activity. Individual results vary.

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Brand-name Foundayo™
Foundayo (orforglipron) tablets in official Lilly packaging

One tablet. Once a day.

Brand-name Foundayo™ by Eli Lilly, prescribed online and shipped to your door through licensed pharmacy partners.

Type
Oral GLP-1 tablet
Frequency
Once daily
Food
With or without
Status
FDA-approved
Manufacturer
Eli Lilly
Woman on an outdoor trail holding a water bottle and a Foundayo tablet in her open palm

Designed for flexibility

Fits into your day, not the other way around

A GLP-1 that behaves like an ordinary pill — take it with breakfast, at your desk, or after a walk.

  • No injections

    A small tablet, once a day.

  • No fasting window

    Take it with or without food, at any time.

  • No refrigeration

    Store at room temperature — travel-friendly.

  • No special morning ritual

    Fits alongside your other medications.

Clinical trial highlight

11.1%

average body-weight reduction at 17.2 mg at Week 72 in Trial 1, versus 2.1% with placebo. See the data

Why Foundayo™

How a once-daily pill supports weight loss

Orforglipron is a small-molecule GLP-1 receptor agonist — the same receptor as injectable GLP-1s, in a form the gut absorbs without special handling.

Foundayo tablet beside a glass of water and a breakfast bowl — take it any time of day, with or without food
  1. Take one tablet daily

    At a consistent time that suits you — with or without food.

  2. Activates GLP-1 receptors

    In the brain, gut, and pancreas — the pathway that regulates appetite and fullness.

  3. Quiets hunger, extends fullness

    Gastric emptying slows and hunger signals settle, so smaller portions feel natural.

  4. Supports weight loss with diet and exercise

    Alongside a reduced-calorie eating pattern and increased physical activity.

Clinical results

Meaningful weight reduction in a once-daily pill

In Trial 1 (ATTAIN-1), adults with obesity — or overweight with a weight-related condition — taking Foundayo™ 17.2 mg lost an average of 11.1% of body weight at Week 72, versus 2.1% with placebo, alongside a reduced-calorie diet and increased physical activity.

17.2 mg dose

11.1%

average body-weight reduction at Week 72 (Trial 1).*

Placebo

2.1%

average body-weight reduction at Week 72 in the same trial.*

Dose-dependent results at Week 72

  • 5.5 mg7.4%
  • 9 mg8.3%
  • 17.2 mg11.1%
  • Placebo2.1%
Foundayo graphic: lose 11% of your body weight on average at 72 weeks, with diet and exercise
Foundayo example graphic: at 252 lbs, you could lose about 27 lbs on average at 72 weeks
Illustrative example based on the 11.1% trial average. Try the BMI Calculator or GLP-1 Screener for your own numbers.

*Trial 1 (ATTAIN-1): 72-week, randomized, placebo-controlled study of orforglipron in adults with obesity, or overweight plus a weight-related condition, alongside a reduced-calorie diet and increased physical activity. Treatment-regimen estimand. Individual results vary; no specific outcome is guaranteed.

Dosing

Start low. Increase gradually.

Foundayo™ starts at 0.8 mg once daily and steps up with at least 30 days between increases. Your provider decides whether — and how far — to increase based on response and tolerability.

Foundayo available in 6 doses — tablets increasing in size from starter dose 1 to maintenance dose 6
  1. Starting

    0.8 mg

    once daily

  2. Step 1

    2.5 mg

    once daily

  3. Step 2

    5.5 mg

    once daily

  4. Step 3

    9 mg

    once daily

  5. Step 4

    14.5 mg

    once daily

  6. Maximum

    17.2 mg

    once daily

Allow at least 30 days between dose increases. Not every patient needs the highest dose.

Your oral options

Foundayo™ vs Wegovy® pill

Two FDA-approved once-daily GLP-1 tablets — different molecules, different daily routines.

Fingers holding a small Foundayo tablet — daily GLP-1 pill, no injections needed
Foundayo™Wegovy® pill
Active ingredientOrforglipron (small molecule)Semaglutide (peptide)
FrequencyOnce dailyOnce daily
Food & timingAny time, with or without foodEmpty stomach, ≤4 oz water, wait 30 min
ReceptorsGLP-1GLP-1
Dose range0.8–17.2 mg1.5–25 mg
ManufacturerEli LillyNovo Nordisk

Curious about the semaglutide tablet? Learn about the Wegovy® pill.

The process

From assessment to ongoing support

Personalized care, every step of the way.

  1. 1.

    Complete your online visit

    Share your health history and goals from home — about 10 minutes.

  2. 2.

    Provider reviews and prescribes if appropriate

    A licensed provider decides whether Foundayo™ — or another option — fits you.

  3. 3.

    Transparent self-pay pricing

    Your total cost is confirmed before you commit — no insurance, no surprise bills.

  4. 4.

    Shipped to your door

    Brand-name Foundayo™ ships discreetly through licensed pharmacy partners.

  5. 5.

    Ongoing support

    Dose adjustments, check-ins, and real people who care.

Severe gastrointestinal reactions

Nausea, vomiting, and diarrhea can be severe, especially around dose increases. Tell your provider if symptoms don't ease.

Acute kidney injury

Vomiting or diarrhea can cause dehydration and worsen kidney function; stay hydrated.

Gallbladder disease

Gallstones and gallbladder inflammation have been reported; watch for upper-abdominal pain, fever, or yellowing of the skin.

Pancreatitis

Stop use and seek care for severe, persistent abdominal pain, with or without vomiting, that may radiate to the back.

Hypoglycemia

Risk is higher when used with insulin or sulfonylureas; know the signs of low blood sugar.

Oral contraceptive interaction

Foundayo™ can reduce the effectiveness of oral hormonal contraceptives. Switch to a non-oral method, or add a barrier method, for 30 days after starting and for 30 days after each dose escalation.

Severe allergic reactions

Stop use and get emergency help for swelling, trouble breathing, rapid heartbeat, or severe rash.

Pregnancy, mood & other medications

Do not use if pregnant or planning pregnancy. Report depression or suicidal thoughts, and tell your provider about every medication you take.

Common side effects

Nausea, diarrhea, vomiting, constipation, abdominal pain, decreased appetite, indigestion, headache, and dizziness.

Provider-guided

A short checklist before your first tablet.

Your provider reviews your BMI and weight-related conditions, personal and family thyroid history, pancreatitis and gallbladder history, kidney function, contraception, current medications, and pregnancy plans before prescribing Foundayo™.

Woman on a sunny trail pausing with a water bottle and her daily Foundayo tablet
Questions

Foundayo™ FAQ

Both are FDA-approved oral GLP-1 medications, but Foundayo™ (orforglipron) is a non-peptide small molecule. It's taken once daily at any time, with or without food, and needs no fasting window. The Wegovy® pill (semaglutide) is a peptide that must be taken on an empty stomach with a small amount of water followed by a 30-minute wait.

Explore more treatments

Other FDA-approved weight-management options

Daily tabletFDA-approved

Wegovy® pill

Semaglutide in a once-daily oral tablet with a fasting routine.

Learn More
Weekly injectionFDA-approved

Wegovy® pen

Semaglutide, a GLP-1-only injection with a higher-dose HD option for eligible patients.

Learn More
Weekly injectionFDA-approved

Zepbound®

Tirzepatide, a dual GIP/GLP-1 injection in a single-dose pen.

Learn More
Weekly injectionFDA-approved

Zepbound® KwikPen®

The same tirzepatide in a multi-dose pen — four weekly doses per device.

Learn More
Get started

One pill a day. A plan built around you.

Take a private assessment and a licensed provider will tell you whether Foundayo™ — or another option — fits your history, routine, and goals.

Prescription required. Foundayo™ is a trademark of Eli Lilly and Company; Wegovy® is a registered trademark of Novo Nordisk A/S. Graceland Wellness is not affiliated with either manufacturer. Transparent self-pay pricing; medication ships directly to your door.