What is Endura?
A compounded ED treatment containing sildenafil 55 mg and tadalafil 12.5 mg in one patient-specific orally disintegrating tablet.
Compounded ED Care
Endura™
Sildenafil + Tadalafil ODT
Earlier support meets a longer treatment window. Endura combines sildenafil and tadalafil in one fast-dissolving, provider-prescribed formulation for erectile dysfunction when clinically appropriate.
- Two PDE5 inhibitors combined in one patient-specific compounded ODT.
- Sildenafil contributes the earlier treatment profile; tadalafil contributes longer-lasting PDE5 activity.
- Designed to dissolve under the tongue without water.
- Available only after evaluation by a licensed healthcare provider.
Compounded medications are not FDA-approved. Individual response, onset, and duration vary. Sexual stimulation is required for PDE5 inhibitors to support an erectile response.
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Compounded ED Care
Meet Endura™
Compounded sildenafil 55 mg + tadalafil 12.5 mg in one fast-dissolving ODT.
- Form
- Orally disintegrating tablet
- Active ingredients
- Sildenafil + Tadalafil
- Strength
- 55 mg + 12.5 mg
- Use
- As directed before sexual activity
- Prescription
- Provider evaluation required
Meet Endura
Understand Endura in three cards.
A streamlined product story: what it is, why the formulation is different, and what the ODT format means for everyday use.
Why combine them?
Both act on the PDE5 pathway, but their pharmacokinetic profiles differ. Sildenafil contributes earlier activity while tadalafil contributes a longer treatment window.
Why an ODT?
The tablet is designed to dissolve under the tongue without water, offering a discreet, convenient alternative to swallowing a conventional tablet.
How Endura Works
A provider-guided, visual explanation.
This educational graphic helps explain how Endura's dual PDE5 ingredients support the body's natural erectile response during sexual stimulation.
Balanced Dual-Action Profile
Two complementary ingredients, one combined tablet.
Sildenafil is the relatively faster-acting component and tadalafil the longer-acting component, together in a provider-guided compounded ODT.
Why this matters
Endura gives patients a clearer understanding of what makes the compounded formulation distinct from a single-ingredient option.
Earlier support: sildenafil contributes the relatively faster treatment profile.
Extended window: tadalafil contributes longer-lasting PDE5 activity.
One convenient format: both are combined in a single fast-dissolving ODT.
Provider-guided care: treatment choice still depends on history, safety, prior response, and clinical judgment.
Onset and duration vary by individual. Nothing on this page is a guarantee of results.
Why Two Ingredients?
Same core pathway. Different treatment profiles.
Sildenafil and tadalafil are both PDE5 inhibitors. Their difference is primarily how quickly and how long each medication is present in the body.
Sildenafil
55 mg per Endura ODT
Supports the nitric-oxide/cGMP pathway involved in increasing blood flow to erectile tissue during sexual stimulation. Sildenafil has the relatively shorter and earlier pharmacokinetic profile.
Earlier treatment profileTadalafil
12.5 mg per Endura ODT
Works through the same PDE5 pathway but remains in the body substantially longer, contributing to a broader treatment window for erectile responsiveness.
Extended treatment windowHow to Take Endura
Simple by design. Follow your provider's instructions.
The prescribing instructions below reflect the compounded sildenafil/tadalafil ODT formulation used as the clinical reference.
Place and dissolve.
Place one ODT under the tongue approximately 30 minutes before anticipated sexual activity and allow it to dissolve without water.
Plan around food and alcohol.
A heavy high-fat meal may delay sildenafil absorption. Heavy alcohol intake can increase the chance of dizziness or low blood pressure.
Do not exceed your prescribed dose.
No more than one dose should be taken in 24 hours. Always follow your clinician's instructions for your specific prescription.
Care That Fits Real Life
ED treatment should feel private, simple, and personal.
Endura is one option your provider may consider based on your medical history, previous treatment experience, goals, and safety profile.
Your Path to Endura
From private assessment to ongoing care.
Endura is prescription-only. A licensed provider determines whether this compounded formulation is appropriate for you.
- 01Online
Private online assessment
Share your medical history, medications, ED symptoms, previous treatments, and goals.
- 02Clinical
Licensed provider review
Your provider evaluates cardiovascular safety, medication interactions, and whether Endura may be clinically appropriate.
- 03Private
Prescription and fulfillment
If prescribed, your patient-specific compounded medication is prepared and shipped directly to your door.
- 04Ongoing
Ongoing support
Follow up with your care team about response, side effects, questions, or whether treatment needs adjustment.
Sexual stimulation is still required.
PDE5 inhibitors support the normal erectile response to sexual stimulation; they do not automatically cause an erection.
Tell your provider about all medications and supplements.
Important interactions can occur with nitrates, alpha-blockers, some strong CYP3A4 inhibitors, blood-pressure medications, heavy alcohol use, and other therapies.
Common PDE5 side effects can occur.
These may include headache, flushing, nasal congestion, indigestion, dizziness, visual changes, back pain, or muscle discomfort. Your individual risk depends on your health and other medications.
Know when to seek urgent care.
Seek emergency care for an erection lasting more than 4 hours. Sudden vision or hearing changes also require prompt medical attention.
This is a compounded medication.
Compounded medications are prepared for an individual patient based on a prescription and are not FDA-approved as finished drug products. Safety and efficacy for this specific combination have not been evaluated by the FDA.
Endura FAQ
Endura, explained.
Clear answers to the questions patients are most likely to ask before starting treatment.
Endura is Graceland Wellness's name for a provider-prescribed compounded sildenafil 55 mg / tadalafil 12.5 mg orally disintegrating tablet. It is considered only after a licensed provider evaluates whether the formulation is appropriate for you.
Sildenafil and tadalafil are PDE5 inhibitors. During sexual stimulation, they support the nitric-oxide/cGMP pathway that helps relax smooth muscle and increase blood flow to erectile tissue. The two ingredients have different pharmacokinetic profiles, which is why the formulation is positioned around earlier support plus a longer treatment window.
For the current referenced formulation, one ODT is placed under the tongue approximately 30 minutes before anticipated sexual activity and allowed to dissolve without water. Do not take more than one dose in 24 hours, and always follow your own provider's instructions.
No. PDE5 inhibitors require sexual stimulation to support an erectile response.
No. Nitrates and recreational nitrites can interact with PDE5 inhibitors and cause a dangerous drop in blood pressure. Tell your provider about all medications, supplements, and recreational substances you use.
PDE5-class side effects may include headache, flushing, nasal congestion, indigestion, dizziness, visual symptoms, back pain, or muscle discomfort. Because Endura combines sildenafil and tadalafil, your provider should review whether cumulative PDE5 exposure is appropriate for you.
No. Endura uses a patient-specific compounded sildenafil/tadalafil formulation. Compounded drugs are not FDA-approved as finished products, and the FDA does not evaluate them for safety, effectiveness, or quality before marketing in the same way it evaluates approved drugs.
Graceland offers other provider-guided ED and sexual-health options. Your clinician can help determine which treatment approach best fits your health history, preferences, and goals.
Other Men's Sexual Health Options
Explore alternatives with your provider.
Endura is one option. Treatment selection should be based on medical history, previous response, timing preferences, safety, and your individual goals.
Brand Name
Cialis®
Brand-name tadalafil with as-needed or daily approaches when appropriate.
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PrimeRise™
Tadalafil + Oxytocin ODT in a provider-guided compounded formulation.
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Personalized ED Care
Find out if Endura fits your health, goals, and treatment preferences.
Complete a private assessment and connect with a licensed provider who can determine whether Endura or another ED treatment may be appropriate.
Prescription required. Treatment availability may vary by state and clinical eligibility. Compounded medications are not FDA-approved.