What is PrimeRise?
PrimeRise™ is a provider-guided compounded tadalafil + oxytocin ODT — a discreet, fast-dissolving option within Graceland Wellness's men's sexual health offering.
Compounded ED & Intimacy Care
PrimeRise™
Tadalafil + Oxytocin ODT
Confidence that feels more natural. A fast-dissolving compounded ODT designed for men who want care that feels discreet, personalized, and thoughtfully provider-guided.
- Tadalafil supports the erectile-response pathway through PDE5 inhibition.
- Oxytocin adds a complementary neurohormonal component associated with intimacy and connection pathways.
- Sublingual ODT designed to dissolve under the tongue without water.
- Prescription-only compounded care selected by a provider when clinically appropriate.
PrimeRise is a compounded medication and is not FDA-approved as a finished drug product. Treatment requires provider evaluation and a patient-specific prescription. Individual response varies.
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Compounded ED & Intimacy Care
PrimeRise™ · Tadalafil + Oxytocin ODT
One provider-guided compounded ODT.
- Form
- Sublingual orally disintegrating tablet
- Active ingredients
- Tadalafil + Oxytocin
- Care model
- Provider-guided compounded prescription
- Focus
- Confidence, intimacy & connection
- Prescription
- Provider evaluation required
PrimeRise Overview
Understand PrimeRise in three cards.
What the medication is, why the formulation is distinct, and why the ODT format matters in everyday use.
Why is it different?
Unlike a pure PDE5 formulation, PrimeRise adds oxytocin, a neurohormonal component associated with intimacy and connection, alongside the familiar erectile-response pathway.
Why the ODT format?
The sublingual ODT is designed to dissolve under the tongue without water — convenient, private, and simple to fit into your routine.
Meet PrimeRise
One ODT, two complementary components.
An at-a-glance look at the dual-component formula, the sublingual ODT format, and the compounded prescription positioning.
How PrimeRise Works
Two pathways. One premium product story.
The ODT dissolves under the tongue; tadalafil supports PDE5 inhibition, which supports cGMP activity and smooth muscle relaxation, while oxytocin is associated with intimacy and connection pathways.
Dual-Ingredient Story
Two ingredients. One ODT.
The formulation story at a glance, before the ingredient detail below.
Inside the Formulation
What each component contributes.
Tadalafil provides the clinical grounding; oxytocin adds a complementary neurohormonal layer.
Tadalafil
PDE5 erectile-response support
Tadalafil is the PDE5 component of PrimeRise. It anchors the familiar erectile-response pathway, supporting smooth muscle relaxation and blood flow during sexual stimulation.
Erectile-response pathwayOxytocin
Complementary neurohormonal component
Oxytocin is a naturally occurring neurohormone associated with intimacy, bonding, and connection pathways. It is included as a complementary component and is described here in educational terms rather than as a guaranteed effect.
Intimacy & connectionA Different Page Story
Treatment is only part of the story.
Sexual health shapes confidence, comfort, intimacy, and how connected you feel. PrimeRise is one provider-guided option within care designed around all of that — not performance alone.
How to Take PrimeRise
Simple by design. Follow your prescription.
Always use PrimeRise exactly as your provider prescribed it for you.
Use only the strength prescribed to you.
PrimeRise is provider-guided compounded care, so dosing should always reflect your specific prescription and clinical plan.
Place the ODT under the tongue.
The tablet is designed to dissolve sublingually without water — a simple, discreet format.
Plan ahead for the timing guidance provided.
Your provider or pharmacy instructions should guide use before anticipated intimacy.
Follow your prescription limits carefully.
Do not exceed the prescribed frequency. Contact your provider with questions about response or side effects.
Your Path to PrimeRise
From private assessment to personalized care.
PrimeRise is prescription-only. A licensed provider determines whether this compounded formulation is appropriate for you.
- 01Assessment
Complete your online assessment
Share your health history, symptoms, goals, and any questions you have about treatment.
- 02Clinical
Provider review
A licensed provider reviews your profile to determine whether PrimeRise or another option may be appropriate.
- 03Personalized
Personalized prescription plan
If prescribed, your plan reflects a provider-guided compounded approach, not a one-size-fits-all product choice.
- 04Support
Discreet follow-up support
Care doesn't end at checkout. Follow-up supports response tracking, questions, and next steps.
Premium Compounded Care
Premium compounded care™
Four things stay true of every PrimeRise prescription.
Compounded prescription treatment. Prepared for an individual patient based on a provider's prescription — never sold over the counter.
Provider evaluated. A licensed clinician reviews your history, medications, and safety profile before anything is prescribed.
Private telehealth process. Assessment, review, and follow-up happen online, on your schedule.
Discreet fulfillment when prescribed. If treatment is appropriate, it ships directly to your door in plain packaging.
Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety or efficacy.
Medication and health review matter.
Tadalafil-containing treatments involve cardiovascular, blood-pressure, and medication-interaction considerations. Clinical review is essential before prescribing.
Sexual stimulation is still required.
PDE5 inhibitors support the normal erectile response to sexual stimulation; they do not automatically cause an erection.
Side effects should be discussed clearly.
Possible PDE5-class effects include headache, flushing, nasal congestion, indigestion, dizziness, back pain, or muscle discomfort. Review your individual risk with your provider.
Know when to seek urgent care.
Seek emergency care for an erection lasting more than 4 hours. Sudden vision or hearing changes also require prompt medical attention.
This is a compounded medication.
Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety or efficacy.
PrimeRise FAQ
PrimeRise, explained.
Clear answers to the questions patients ask most before starting treatment.
Endura is a dual-PDE5 formulation centered on the erectile-response pathway. PrimeRise still addresses erectile response through tadalafil, but adds oxytocin — a component associated with intimacy and connection pathways — giving it a broader focus than performance alone.
PrimeRise is a sublingual orally disintegrating tablet. Place it under the tongue and allow it to dissolve without water, following the strength, timing, and frequency your provider prescribed for you.
No. Tadalafil is a PDE5 inhibitor and requires sexual stimulation to support an erectile response. It does not create arousal on its own.
Oxytocin is a naturally occurring neurohormone associated with intimacy, bonding, and connection pathways. In PrimeRise it is included as a complementary component. This association is not the same as a proven clinical outcome, and your provider can explain what is and is not established.
No. Nitrates and recreational nitrites can interact with PDE5 inhibitors such as tadalafil and cause a dangerous drop in blood pressure. Tell your provider about every medication, supplement, and recreational substance you use.
No. PrimeRise is a patient-specific compounded medication. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety or efficacy.
PrimeRise may not be appropriate if you take nitrates, have certain cardiovascular conditions, uncontrolled blood pressure, or take interacting medications. A licensed provider reviews your history before deciding whether treatment is suitable.
Graceland Wellness offers other provider-guided men's sexual health options, including Endura™, tadalafil, Viagra®, and Cialis®. Your clinician can help identify the approach that best fits your history and goals.
Other Men's Sexual Health Options
Explore additional provider-guided treatments.
PrimeRise is one option. Treatment selection should be based on medical history, previous response, timing preferences, safety, and your individual goals.
Compounded ED Care
Endura™
Sildenafil + tadalafil ODT with a more performance-centered profile.
Learn More
Personalized Sexual Health Care
Confidence that feels more natural.
Start a private assessment and a licensed provider will review whether PrimeRise — or another provider-guided option — fits your history, goals, and safety profile.
Prescription required. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety or efficacy.