Hormone therapyFDA-approved
Estradiol Patch
A transdermal estradiol patch worn on the skin, prescribed when clinically appropriate after evaluation.
Learn MorePrescription · Oral Estrogen
Estradiol Tablet
Estradiol · Once-Daily Oral Tablet
Estradiol is the body's primary biologically active estrogen. Taken as a once-daily tablet, it can help relieve common symptoms of menopause — such as hot flashes and night sweats — with dosing guided by a licensed provider.
- Systemic estrogen support for symptoms like hot flashes and night sweats
- One daily oral tablet — no patches, applicators, or injections
- Available as a tablet, with dosing determined by your provider
Prescription required. Estrogen therapy carries important risks, including an increased risk of endometrial cancer in women with a uterus who use estrogen without a progestin — see full safety information below. A licensed provider will review your health history before determining whether treatment is appropriate.
A simple daily routine
One tablet, once a day — easy to fit into a morning or evening routine.
Photography shows illustrative tablet imagery; the appearance of the dispensed product may vary.
- Type
- Oral estrogen
- Frequency
- Once daily
- Status
- FDA-approved
- Form
- Tablet
- Access
- Prescription required
Support
Feel more supported through hormonal change
Steadier days can start here
Menopause symptoms are common, and they're treatable. Many women find that the right support makes a real difference in how they feel day to day.
Steadier days. Systemic estrogen can ease hot flashes and night sweats that interrupt work, rest, and everything in between.
Care that stays with you. Your provider follows your progress and adjusts your plan as your needs change.
Private by design. Everything happens online and at home — no waiting rooms, no judgment.
How it works
A simple, private care path
From first questions to ongoing follow-up, every step happens privately online.
- 01Step 1
Start your assessment
Answer a few confidential questions about your symptoms, health history, and goals — it takes just a few minutes.
- 02Step 2
Licensed-provider review
A provider licensed in your state reviews your information and determines whether estradiol is appropriate and safe for you.
- 03Step 3
Personalized care plan
If prescribed, your medication ships directly to your door, with follow-up support to check in on how you're feeling.
Private care
Talk to a provider about your symptoms — privately, from home.
A free, confidential assessment is the first step. No commitment, no waitlists.
Start My AssessmentOverview
Estradiol is the body's primary biologically active estrogen
Oral hormone support, made simple
Estradiol tablets replace some of the estrogen the body naturally makes less of during menopause. Taken by mouth once a day, the medication circulates throughout the body.
What it is. A prescription oral form of estradiol — the same estrogen your ovaries produced before menopause — used to treat moderate to severe menopause symptoms.
What it may support. Relief from hot flashes, night sweats, and related symptoms, and support for bone health in appropriate patients, as determined by your provider.
How it's taken. One tablet by mouth daily, at a dose your provider selects based on your symptoms and health history.
Estradiol tablets are FDA-approved prescription medication. Treatment is always guided by a licensed provider.
At a glance
Support for menopause symptoms
Compare
Not every estrogen treatment works the same way
Oral estradiol is a systemic treatment — it circulates throughout the body. If symptoms are limited to vaginal or vulvar discomfort only, local estrogen options may be discussed separately with a provider.
| Estradiol Tablet | Local Vaginal Estrogen | |
|---|---|---|
| How it's taken | Oral tablet, once daily | Cream, tablet, or ring placed in the vagina |
| Where it works | Systemic — throughout the whole body | Local — mostly vaginal and vulvar tissue |
| Commonly considered for | Hot flashes, night sweats, and other whole-body symptoms | Vaginal dryness or discomfort, when those are the only symptoms |
| Decided by | Your provider, based on your symptoms, anatomy, and health history | |
Safety & Questions
Important safety information and answers
Estrogen therapy is effective for many women, but it isn't right for everyone. Review the safety information below, and talk with your provider about your full health history.
Boxed Warning: Endometrial Cancer
Estrogens increase the risk of endometrial cancer in women with a uterus who use estrogen without a progestin. Report any unexpected or persistent vaginal bleeding to your provider promptly — this can be an early sign of a problem that needs evaluation. Your provider may use diagnostic measures, including endometrial sampling, to rule out cancer in cases of undiagnosed, persistent, or recurring abnormal bleeding.
Estrogen therapy, with or without a progestin, has been associated in some studies with increased risk of stroke and blood clots (including deep vein thrombosis and pulmonary embolism), and should not be used for the prevention of heart disease. Your provider will review your personal and family health history — including any history of blood clots, stroke, heart disease, or breast cancer — before determining whether estrogen therapy is appropriate for you and at what dose.
If you have a uterus, taking estrogen alone — without a progestin — increases the risk of endometrial cancer. For this reason, women with a uterus who take systemic estrogen are typically also prescribed a progestin, which helps protect the uterine lining. Your provider will determine whether a progestin should be part of your treatment plan based on your individual anatomy and health history. If you've had a hysterectomy and no longer have a uterus, this consideration typically doesn't apply — your provider will confirm what's appropriate for you.
Estrogen therapy may not be appropriate for women with any of the following. This list is informational, not exhaustive — a licensed provider makes the actual eligibility determination based on your full health history:
- Undiagnosed abnormal vaginal bleeding
- A personal history of certain estrogen-sensitive cancers (including breast or endometrial cancer)
- A current or prior history of blood clots (deep vein thrombosis or pulmonary embolism), stroke, or heart attack
- Active liver disease
- Known or suspected pregnancy
- Known hypersensitivity to estradiol or any component of the formulation
Take one tablet by mouth once daily, with or without food, at roughly the same time each day. Your provider will choose your starting dose and may adjust it based on how you respond.
Some women notice improvement in hot flashes within a few weeks, while full benefit can take longer. Your provider will check in on your progress and adjust your plan if needed.
Take it as soon as you remember, unless it's almost time for your next dose — in that case, skip the missed dose and continue your normal schedule. Don't take two doses at once.
Yes. Your care includes follow-up support so your provider can see how you're feeling, answer questions, and adjust your treatment over time.
Explore
Related treatments
Other options your provider may consider as part of a personalized women's-health plan.
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Vaginal Wellness
Care focused on vaginal dryness and comfort, including local estrogen options when symptoms are limited to that area.
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Low Libido & Desire
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Support that meets you where you are
Menopause symptoms are common, and treatment is available. Start with a private assessment to find out if estradiol is right for you.
Prescription required. A licensed provider reviews your health history before any treatment is prescribed. Cash-pay pricing — no insurance needed, and shipping is always free.